Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review

Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review

This article will describe some of the commonly prescribed muscle relaxants. We will also discuss which muscle relaxant is best for different indications what is the maximum dose of flexeril (types of muscle pain). Baclofen’s drug interactions can include prescription medications, over the counter medications, vitamins, and herbal products.

  • Antispasmodics have more side effects than NSAIDs and acetaminophen, so it’s important to talk to your healthcare provider about the benefits and risks of taking these medications.
  • For persistent pain, your primary care physician may recommend muscle relaxants.
  • Therefore, there needs to be a closer look at Flexeril vs. Baclofen to weigh out the side effects of each.
  • It is worth noting that muscle relaxant medications are intended for short-term relief and not chronic pain.
  • Additionally, cyclobenzaprine antagonizes the alpha1 adrenergic receptor, causing a vasodilatory effect, and may contribute further to reflex tachycardia.

Flexeril (Cyclobenzaprine) is indicated for treating pain and muscle spasms related to short-term skeletal problems and muscle pain. It acts on the brain stem region, relieving short-term musculoskeletal pain and improves mobility. Cyclobenzaprine relieves skeletal muscle spasm of local origin without interfering with muscle function.

Baclofen vs. Flexeril Side Effects, Strengths, Interactions

Both baclofen and cyclobenzaprine carry significant adverse effects, and you should seek professional medical advice to determine which is best for you. Be aware of contraindications and drug interactions when taking these medications. Conservative treatment, such as physical therapy, exercise, and nonsteroidal anti-inflammatory drugs (NSAIDs), should always be the first line of treatment for muscle spasm and related pain. assumes no responsibility for any healthcare administered to a person based on the information found on this site. For most patients, the recommended dose of Flexeril is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of Flexeril for periods longer than two or three weeks is not recommended. Additionally, if you’re pregnant or nursing, you should use baclofen only if the perceived benefits of the drug outweigh the risks to the fetus or infant (2). Don’t opt for an excessively long treatment duration with baclofen, as you might find yourself dealing with life-threatening withdrawal symptoms as you try to wind down the treatment.


Tizanidine is also used in conjunction with physical therapy, which may be too uncomfortable without the medication. Various musculoskeletal conditions can lead to tense, cramping muscles or muscle spasms. Muscle spasticity occurs when skeletal muscles contract involuntarily and cannot relax. The symptoms can range from mild discomfort to intense, severe pain. Gablofen over-the-counter alternatives can also be used as therapy for muscle spasms caused by acute lower back pain, tension headaches, or other similar conditions in different patients.

If the damage is more systemic in the lungs and I like tinctures and so a lot of the studies that have been done, tinctures are a good way to go and it is the oldest form of taking cannabis. So, um, you know, a lot of these folks who are listening, a lot of folks that listen to this show work with COPD patients like I do. Each person experiences this differently and while some people report pressure or a cyclobenzaprine sensation around the ribs, source report more typical sharp or stabbing pain. Agents acting at the neuromuscular junction and autonomic ganglia. Expert review of hepatotoxicity published in discusses dantrolene, chlorzoxazone and baclofen but does not mention cyclobenzapine.

Providers mainly prescribe antispasmodic skeletal muscle relaxants for musculoskeletal and myofascial pain, especially lower back pain, and muscle spasms. Tizanidine can also be used to treat medical conditions that cause muscle tension and spasticity like multiple sclerosis. For these issues, muscle relaxants like tizanidine represent an important alternative to other pain relief options like opioids.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice. Cyclobenzaprine functions as a depressant and sedative agent for the central nervous system, specifically acting on the spinal cord and reducing muscle hyperactivity (8). Muscles are innervated (stimulated to action) by nerves from the spinal cord, and cyclobenzaprine dulls the signals sent out by these nerves. By inhibiting these signals, cyclobenzaprine reduces or even eliminates muscle spasms.

Baclofen Addiction and Abuse – Get Help Today – Addiction Center

Baclofen Addiction and Abuse – Get Help Today.

Posted: Wed, 22 Mar 2023 07:00:00 GMT [source]

Tense, aching muscles can be frustrating, distracting, and throw a wrench into your schedule. When muscle pain hits, it can have you looking for fast-acting relief so you can get on with life. Whether you experience back pain, muscle spasms, arthritis, injury-related chronic pain, or even TMJ, muscle relaxers offer fast pain relief, allowing your body to function as usual. Consider this guide your roadmap to the best muscle relaxers on the market. Although antispastics and antispasmodics are both types of skeletal muscle relaxants, they have specific and different uses.

He has a particular interest in psychopharmacology, nutritional psychiatry, and alternative treatment options involving particular vitamins, dietary supplements, and administering auricular acupuncture. According to the FDA, Lioresal belongs to the C pregnancy category. That means the effects of doses of Lioresal medication on pregnant women have not been studied yet.